BDBM8906 6-(pyridin-3-yl)naphthalen-2-ol::6-Pyridin-3-ylnaphthalen-2-ol::Pyridine-substituted naphthalene 3::US9271963, 3

SMILES Oc1ccc2cc(ccc2c1)-c1cccnc1

InChI Key InChIKey=MDXMZUQFVFTPDO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 8906   

TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

LigandPNGBDBM8906(6-Pyridin-3-ylnaphthalen-2-ol | 6-(pyridin-3-yl)na...)
Affinity DataIC50: 2.67E+3nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University

LigandPNGBDBM8906(6-Pyridin-3-ylnaphthalen-2-ol | 6-(pyridin-3-yl)na...)
Affinity DataIC50: 23nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Saarland University

LigandPNGBDBM8906(6-Pyridin-3-ylnaphthalen-2-ol | 6-(pyridin-3-yl)na...)
Affinity DataIC50: 3.60E+4nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

LigandPNGBDBM8906(6-Pyridin-3-ylnaphthalen-2-ol | 6-(pyridin-3-yl)na...)
Affinity DataIC50: 715nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University

LigandPNGBDBM8906(6-Pyridin-3-ylnaphthalen-2-ol | 6-(pyridin-3-yl)na...)
Affinity DataIC50: 23nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetAromatase(Human)
Saarland University

LigandPNGBDBM8906(6-Pyridin-3-ylnaphthalen-2-ol | 6-(pyridin-3-yl)na...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of aromataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed