BDBM8913 3-(1-Chloro-7-methoxy-2-naphthyl)pyridine::3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine::Pyridine-substituted naphthalene 14::US9271963, 14

SMILES COc1ccc2ccc(-c3cccnc3)c(Cl)c2c1

InChI Key InChIKey=KRLGQBXIHBDUPS-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 8913   

TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8913(3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of human CYP11B1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAromatase(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8913(3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP19 in human placental microsomes using [1beta-3H]androstenedione as substrate by 3H2O-methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8913(3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human CYP11B2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8913(3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human CYP17More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8913(3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 2.72E+3nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8913(3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 29nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8913(3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 3.60E+4nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2006
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8913(3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 27nMAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8913(3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 771nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8913(3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 29nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)

Curated by ChEMBL
LigandPNGBDBM8913(3-(1-chloro-7-methoxynaphthalen-2-yl)pyridine | 3-...)
Affinity DataIC50: 27nMpH: 7.4 T: 2°CAssay Description:A solution of 6.25 nmol of progesterone (in 5 μl of MeOH) was dissolved in 140 μl of phosphate buffer (0.05 M; pH 7.4; 1 mM MgCl2; 0.1 mM EDTA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent