BDBM8916 1-(2-Naphthyl)-1H-imidazole::1-(naphthalen-2-yl)-1H-imidazole::Imidazole-substituted naphthalene 23::US9271963, 23

SMILES c1cn(cn1)-c1ccc2ccccc2c1

InChI Key InChIKey=LHAAPZJTEBPKBJ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 8916   

TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

LigandPNGBDBM8916(1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...)
Affinity DataIC50: 1.32E+3nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University

LigandPNGBDBM8916(1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...)
Affinity DataIC50: 39nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2006
Entry Details Article
PubMed
TargetAromatase(Human)
Saarland University

LigandPNGBDBM8916(1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...)
Affinity DataIC50: 2.82E+3nMAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

LigandPNGBDBM8916(1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...)
Affinity DataIC50: 1.05E+3nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University

LigandPNGBDBM8916(1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...)
Affinity DataIC50: 38nMT: 2°CAssay Description:V79 MZh11B1 and V79 MZh 11B2 cells (8˙10^5 cells per well) were grown to confluency on 24-well cell culture plates with 1.9 cm^2 culture area per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetAromatase(Human)
Saarland University

LigandPNGBDBM8916(1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...)
Affinity DataIC50: 2.82E+3nMpH: 7.4Assay Description:The enzyme was obtained from the microsome fraction of fresh human placenta (St. Josephs Krankenhaus, Saarbrucken-Dudweiler, Germany) according to th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetAromatase(Human)
Saarland University

LigandPNGBDBM8916(1-(2-Naphthyl)-1H-imidazole | 1-(naphthalen-2-yl)-...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of aromataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed