BDBM9049 US11419874, Example 15::US8829010, 35::US8829010, 55

SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=SHAVEYUXRBIMLA-UHFFFAOYSA-N

Data  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 9049   

LigandPNGBDBM9049(US8829010, 35 | US8829010, 55 | US11419874, Exampl...)
Affinity DataIC50: 1.48nMAssay Description:In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2015
Entry Details
Go to US Patent

LigandPNGBDBM9049(US8829010, 35 | US8829010, 55 | US11419874, Exampl...)
Affinity DataIC50: 1.67nMAssay Description:In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2015
Entry Details
Go to US Patent

LigandPNGBDBM9049(US8829010, 35 | US8829010, 55 | US11419874, Exampl...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
LigandPNGBDBM9049(US8829010, 35 | US8829010, 55 | US11419874, Exampl...)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to PDE2A in rat striatal membranes after 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2019
Entry Details Article
PubMed
LigandPNGBDBM9049(US8829010, 35 | US8829010, 55 | US11419874, Exampl...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2019
Entry Details Article
PubMed
LigandPNGBDBM9049(US8829010, 35 | US8829010, 55 | US11419874, Exampl...)
Affinity DataIC50: 2.30nMAssay Description:Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

LigandPNGBDBM9049(US8829010, 35 | US8829010, 55 | US11419874, Exampl...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM9049(US8829010, 35 | US8829010, 55 | US11419874, Exampl...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed