BDBM917 (1S-(1R*,2S*(2S*,3S*)))-[3-[[3-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl]amino]-2-hydroxy-1-(2-phenylethyl)propyl]carbamic Acid, 1,1-Dimethylethyl Ester::Aminodiol deriv. 15a::tert-butyl N-[(2S,3R)-4-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-5-phenylpentyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate

SMILES CC(C)(C)OC(=O)N[C@@H](CCc1ccccc1)[C@H](O)CNC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C

InChI Key InChIKey=LPPXRQSRGPFEKI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 917   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol-Myers Squibb

LigandPNGBDBM917(tert-butyl N-[(2S,3R)-4-{[(2R,3S)-3-{[(tert-butoxy...)
Affinity DataIC50: 500nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2004
Entry Details Article
PubMed