BDBM92606 DHOD Inhibitor, 5::US8703811, 6

SMILES CCOC(=O)c1[nH]c(C)c(Cc2ccc(OCC)cc2)c1C

InChI Key InChIKey=AHTZIFIBNCSFEG-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 92606   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. falciparum)
Harvard Medical School

LigandPNGBDBM92606(US8703811, 6 | DHOD Inhibitor, 5)
Affinity DataIC50: 83nMAssay Description:Assay was determined using a continuous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei (strain Anka))
Harvard Medical School

LigandPNGBDBM92606(US8703811, 6 | DHOD Inhibitor, 5)
Affinity DataIC50: 60nMAssay Description:Assay was determined using a continuous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium vivax)
Harvard Medical School

LigandPNGBDBM92606(US8703811, 6 | DHOD Inhibitor, 5)
Affinity DataIC50: 40nMAssay Description:Assay was determined using a continuous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
LigandPNGBDBM92606(US8703811, 6 | DHOD Inhibitor, 5)
Affinity DataIC50: 3.00E+4nMAssay Description:Assay was determined using a continuous assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. falciparum)
Harvard Medical School

LigandPNGBDBM92606(US8703811, 6 | DHOD Inhibitor, 5)
Affinity DataIC50: 83nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei (strain Anka))
Harvard Medical School

LigandPNGBDBM92606(US8703811, 6 | DHOD Inhibitor, 5)
Affinity DataIC50: 60nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium vivax)
Harvard Medical School

LigandPNGBDBM92606(US8703811, 6 | DHOD Inhibitor, 5)
Affinity DataIC50: 40nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (fumarate)(Baker's yeast)
Genzyme

US Patent
LigandPNGBDBM92606(US8703811, 6 | DHOD Inhibitor, 5)
Affinity DataIC50: 1.00E+4nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

LigandPNGBDBM92606(US8703811, 6 | DHOD Inhibitor, 5)
Affinity DataIC50: 3.00E+4nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

LigandPNGBDBM92606(US8703811, 6 | DHOD Inhibitor, 5)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
Birla Institute of Technology and Science Pilani

Curated by ChEMBL
LigandPNGBDBM92606(US8703811, 6 | DHOD Inhibitor, 5)
Affinity DataIC50: 270nMAssay Description:Inhibition of Plasmodium falciparum DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
LigandPNGBDBM92606(US8703811, 6 | DHOD Inhibitor, 5)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed