BDBM9915 3-[(S)-1H-imidazol-1-yl(4-nitrophenyl)methyl]-4H-chromen-4-one::Nonsteroidal Aromatase Inhibitor 1S

SMILES O=c1c(coc2ccccc12)[C@H](c1ccc(cc1)N(=O)=O)n1ccnc1

InChI Key InChIKey=GQUCRMYPRQVAIK-UHFFFAOYSA-N

Data  1 IC50  1 Other

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 9915   

TargetAromatase(Human)
University of Bologna

LigandPNGBDBM9915(3-[(S)-1H-imidazol-1-yl(4-nitrophenyl)methyl]-4H-c...)
Affinity DataIC50: 96nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta,2beta-3H]testosterone during aromatization. After incubation, the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

LigandPNGBDBM9915(3-[(S)-1H-imidazol-1-yl(4-nitrophenyl)methyl]-4H-c...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed