BDBM9918 4-[(R)-1H-imidazol-1-yl(4-oxo-4H-chromen-3-yl)methyl]benzonitrile::CHEMBL225079::Nonsteroidal Aromatase Inhibitor 3R

SMILES O=c1c(coc2ccccc12)[C@@H](c1ccc(cc1)C#N)n1ccnc1

InChI Key InChIKey=ZYDFLNTVLZWITD-UHFFFAOYSA-N

Data  2 IC50  1 Other

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 9918   

TargetAromatase(Human)
University of Bologna

LigandPNGBDBM9918(CHEMBL225079 | 4-[(R)-1H-imidazol-1-yl(4-oxo-4H-ch...)
Affinity DataIC50: 110nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta,2beta-3H]testosterone during aromatization. After incubation, the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
University of Bologna

LigandPNGBDBM9918(CHEMBL225079 | 4-[(R)-1H-imidazol-1-yl(4-oxo-4H-ch...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Bologna

LigandPNGBDBM9918(CHEMBL225079 | 4-[(R)-1H-imidazol-1-yl(4-oxo-4H-ch...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by liquid scintillation counting in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed