BDBM150162 BI-10773::Jardiance::US8980829, EMPAGLIFLOZIN::empagliflozin

SMILES c1cc(ccc1Cc2cc(ccc2Cl)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O[C@H]4CCOC4

InChI Key InChIKey=OBWASQILIWPZMG-UHFFFAOYSA-N

Data  6 IC50  2 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 150162   

TargetSodium/glucose cotransporter 2(Human)
Shanghai Yingli Science and Technology

US Patent
LigandPNGBDBM150162(US8980829, EMPAGLIFLOZIN | empagliflozin | BI-1077...)
Affinity DataIC50: 3.10nMpH: 7.4Assay Description:A cDNA clone expressing human SGLT1/SGLT2 was bought from GenerScript. Having the sequence information, it was built into pcDNA5 carrier by using tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 1(Human)
Shanghai Yingli Science and Technology

US Patent
LigandPNGBDBM150162(US8980829, EMPAGLIFLOZIN | empagliflozin | BI-1077...)
Affinity DataIC50: 3.24E+3nMpH: 7.4Assay Description:A cDNA clone expressing human SGLT1/SGLT2 was bought from GenerScript. Having the sequence information, it was built into pcDNA5 carrier by using tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSodium/glucose cotransporter 2(Human)
Shanghai Yingli Science and Technology

US Patent
LigandPNGBDBM150162(US8980829, EMPAGLIFLOZIN | empagliflozin | BI-1077...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Shanghai Yingli Science and Technology

US Patent
LigandPNGBDBM150162(US8980829, EMPAGLIFLOZIN | empagliflozin | BI-1077...)
Affinity DataEC50:  3nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 1(Human)
Shanghai Yingli Science and Technology

US Patent
LigandPNGBDBM150162(US8980829, EMPAGLIFLOZIN | empagliflozin | BI-1077...)
Affinity DataEC50:  8.30E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Shanghai Yingli Science and Technology

US Patent
LigandPNGBDBM150162(US8980829, EMPAGLIFLOZIN | empagliflozin | BI-1077...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 1(Human)
Shanghai Yingli Science and Technology

US Patent
LigandPNGBDBM150162(US8980829, EMPAGLIFLOZIN | empagliflozin | BI-1077...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSodium/glucose cotransporter 2(Human)
Shanghai Yingli Science and Technology

US Patent
LigandPNGBDBM150162(US8980829, EMPAGLIFLOZIN | empagliflozin | BI-1077...)
Affinity DataIC50: 3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)