BDBM50406868 BIBW2992::CHEMBL2347958

SMILES CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@@H]1CCOC1

InChI Key InChIKey=ULXXDDBFHOBEHA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50406868   

TargetEpidermal growth factor receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(CHEMBL2347958 | BIBW2992)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human EGFR L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(CHEMBL2347958 | BIBW2992)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(CHEMBL2347958 | BIBW2992)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(CHEMBL2347958 | BIBW2992)
Affinity DataIC50: 5nMAssay Description:Inhibition of wild type EGFR (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(CHEMBL2347958 | BIBW2992)
Affinity DataIC50: 7nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) using FAM-labeled peptide substrate after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(CHEMBL2347958 | BIBW2992)
Affinity DataIC50: 10nMAssay Description:Inhibition of human EGFR T790M/L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(CHEMBL2347958 | BIBW2992)
Affinity DataIC50: 14nMAssay Description:Inhibition of GST-tagged human HER2 catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(CHEMBL2347958 | BIBW2992)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(CHEMBL2347958 | BIBW2992)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of wild type EGFR (unknown origin) expressed in baculovirus expression system by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed