BDBM50466808 AZD-1152-HQPA::Barasertib

SMILES CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1

InChI Key InChIKey=QYZOGCMHVIGURT-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50466808   

TargetAurora kinase B(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50466808BDBM50466808(AZD-1152-HQPA | Barasertib)
Affinity DataIC50: 0.326nMAssay Description:Inhibition of recombinant human full-length His-tagged Aurora B expressed in baculovirus expression system using 5-FAM-LRRASLG-CONH2 as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50466808BDBM50466808(AZD-1152-HQPA | Barasertib)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50466808BDBM50466808(AZD-1152-HQPA | Barasertib)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of recombinant aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50466808BDBM50466808(AZD-1152-HQPA | Barasertib)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50466808BDBM50466808(AZD-1152-HQPA | Barasertib)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Hangzhou Medical College

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50466808BDBM50466808(AZD-1152-HQPA | Barasertib)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of AXL (unknown origin) preincubated for 10 mins followed by substrate and ATP addition and measured after 60 mins by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetAurora kinase A(Human)
Kochi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50466808BDBM50466808(AZD-1152-HQPA | Barasertib)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
Kochi University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50466808BDBM50466808(AZD-1152-HQPA | Barasertib)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed