BDBM50130693 CGP-57380::CHEMBL1240885

SMILES Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12

InChI Key InChIKey=UQPMANVRZYYQMD-UHFFFAOYSA-N

Data  4 KI  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50130693   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 2.74E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Universitat Ramon Llull

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 6.27E+3nMAssay Description:Inhibition of human recombinant full length GST-tagged MNK2 expressed in insect cells using S6 peptide as substrate in presence of [gamma-33P]-ATP in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of human recombinant full length GST-tagged MNK1 expressed in baculovirus expression system using S6 peptide as substrate in presence of [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Universitat Ramon Llull

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of MNK2 (unknown origin) using eIF4E as a substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 870nMAssay Description:Inhibition of MNK1 (unknown origin) using eIF4E as a substrate in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetEukaryotic translation initiation factor 4E(Human)
Ocean University of China and Laboratory For Marine Drugs and Bioproducts

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of eIF4E phosphorylation in HEK293 cells incubated for 60 mins by Western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of MNK1 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Universitat Ramon Llull

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human His6-tagged Mnk2 expressed in Escherichia coli assessed as phosphorylation of eukaryotic translation initiation factor 4EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 870nMAssay Description:Inhibition of human His6-tagged Mnk1 expressed in Escherichia coli assessed as phosphorylation of eukaryotic translation initiation factor 4EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Universitat Ramon Llull

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of MKN2 (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 870nMAssay Description:Inhibition of MKN1 (unknown origin) in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Universitat Ramon Llull

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of MNK2 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 870nMAssay Description:Inhibition of MNK1 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Universitat Ramon Llull

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of MNK2 (unknown origin) using S3 as substrate measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 850nMAssay Description:Inhibition of MNK1 (unknown origin) using S3 as substrate measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Universitat Ramon Llull

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 870nMAssay Description:Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Universitat Ramon Llull

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 45 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Universitat Ramon Llull

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataKi:  340nMAssay Description:Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataKi:  1.01E+3nMAssay Description:Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of CDK9/cyclinT1 (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50130693(CHEMBL1240885 | CGP-57380)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of CDK2/cyclinA (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed