BDBM50042493 CGS-23885::CHEMBL116719::N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea

SMILES NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1

InChI Key InChIKey=FPOBKZCHKXONBB-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50042493   

LigandPNGBDBM50042493(N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]ure...)
Affinity DataIC50: 37nMAssay Description:In vitro 5-lipoxygenase inhibition in guinea pig PMNs was determined based on 5-hydroxyeicosapentaenoic acid (5-HETE) productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

LigandPNGBDBM50042493(N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]ure...)
Affinity DataIC50: 48nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of LTB4 formed in guinea pig polymorphonuclear leukocytes (PMNs).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50042493(N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]ure...)
Affinity DataIC50: 640nMAssay Description:Inhibitory concentration against human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042493(N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]ure...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory concentration against human platelet thromboxane synthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50042493(N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]ure...)
Affinity DataIC50: 40nMAssay Description:In vitro 5-lipoxygenase inhibition in guinea pig PMNs was determined based on LTB4 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProstaglandin G/H synthase 1/2(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042493(N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]ure...)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibitory concentration against sheep seminal vesicle Prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50042493(N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]ure...)
Affinity DataIC50: 43nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of 5-hydroxyeicosatetraenoic acid (5-HETE) formed in guinea pig polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50042493(N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]ure...)
Affinity DataIC50: 890nMAssay Description:Inhibitory concentration against human platelet 5-lipoxygenase in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50042493(N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]ure...)
Affinity DataIC50: 110nMAssay Description:Inhibitory concentration against human platelet 5-lipoxygenase in dog whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed