BDBM21025 (2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanamido]-4-methylpentanoic acid::(D-Ala2,D-Leu5)-Enkephalin::BW-180C::CHEMBL340032::DADLE::DADLE-OH::H-Tyr-D-Ala-Gly-Phe-D-Leu-OH::[D-Ala2-D-Leu5]enkephalin

SMILES CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O

InChI Key InChIKey=ZHUJMSMQIPIPTF-UHFFFAOYSA-N

Data  32 KI  15 IC50  5 Kd  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 58 hits for monomerid = 21025   

TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKd:  0.900nMAssay Description:Opioid receptor mu 1 affinity against the receptor site model site 1 (mu1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKd:  22nMAssay Description:Opioid receptor mu 2 affinity against the receptor site model site 2(mu2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKd:  2.10nMAssay Description:Affinity against the Opioid receptor delta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 48nMAssay Description:Inhibitory potency against Opioid receptor mu 1 in longitudinal muscle preparation of guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 0.540nMAssay Description:Inhibitory potency against delta Opioid receptor delta 1 in longitudinal muscle preparation of mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKd:  625nMAssay Description:Compound was evaluated for Opioid receptor kappa 1 affinity against the receptor site model site 4(kappa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of [3H]-U-69,593 radioligand binding to Guinea pig Opioid receptor kappa 1; not determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 447nMAssay Description:Opioid activity against delta-receptor of isolated mouse vas deferens(MVD) at 30 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of [3H]DADLE radioligand binding to rat brain opioid receptor delta 1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 29nMAssay Description:The opioid activity against the mu-receptor in the isolated guinea pig ileum(GPI)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKd:  1.00E+4nMAssay Description:Compound was evaluated for opioid receptor affinity against the receptor site model site 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 9nMAssay Description:Concentration required to inhibit the specific binding of tritiated ligand [3H]DADL to opiate receptor by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataEC50:  129nMAssay Description:Agonist activity at Rluc-tagged MOR receptor (unknown origin) expressed in human SH-5YSY cells co-expressing RGFP-fused to Gbeta1 assessed as increas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of [3H]- DADLE binding to Rat brain Opioid receptor delta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of [3H]- U69,593 binding to Guinea pig Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 0.360nMAssay Description:Compound was tested for antagonistic activity against opioid receptor in mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataEC50:  1.38E+3nMAssay Description:Agonist activity at Rluc-tagged MOR receptor (unknown origin) expressed in human SH-5YSY cells co-expressing RGFP-fused to MOR/beta-arrestin-2 assess...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataEC50:  54nMAssay Description:Agonist activity at GFP-fused delta opioid receptor (unknown origin) expressed in HEK293 cells assessed as recruitment of beta-arrestin-2 after 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 1.60nMAssay Description:Agonist activity at delta opioid receptor in mouse vas deferens assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataEC50:  1.38E+3nMAssay Description:Agonist activity at Rluc-tagged DOR receptor (unknown origin) expressed in human SH-5YSY cells co-expressing RGFP-fused to Gbeta1 assessed as increas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 42nMAssay Description:Inhibition of [3H]- DAMGO binding to Rat brain Opioid receptor mu 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 447nMAssay Description:Agonistic activity towards Opioid receptor delta 1 as inhibitory activity towards electrically stimulated mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at human DOR expressed in CHOK1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by lumi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 29nMAssay Description:Agonistic activity for Opioid receptor mu 1 as inhibitory activity towards electrically stimulated guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at GFP-fused mu opioid receptor (unknown origin) expressed in HEK293 cells assessed as recruitment of beta-arrestin-2 after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataIC50: 13nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  0.180nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity against Opioid receptor delta 1 in P2 membrane preparation of rat brain by [3H]DADLE displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  0.740nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
Nanjing Medical University

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  1.30nM ΔG°:  -12.1kcal/molepH: 7.4 T: 2°CAssay Description:Log IC50 values for each test compound were determined from nonlinear regression analysis of data collected from two independent experiments performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2008
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  1.65nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetOpioid receptor delta 1(Bovine)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2011
Entry Details
PubMed
TargetDelta-type opioid receptor(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  1.83nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2011
Entry Details
PubMed
TargetDelta-type opioid receptor(Pig)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2011
Entry Details
PubMed
TargetMu-type opioid receptor(Mouse)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  2.49nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  2.85nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetMu-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  3.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetMu-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membranes after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
In Depth
Date in BDB:
11/24/2011
Entry Details
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  4.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2011
Entry Details
PubMed
TargetMu-type opioid receptor(Bovine)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  5.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2011
Entry Details
PubMed
TargetDelta-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  7.70nMAssay Description:Inhibition of [3H]DSLET binding to delta 1 opioid receptors in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  8.20nMAssay Description:Binding affinity against Opioid receptor mu 1 in P2 membrane preparation of rat brain by [3H]DAGO displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  8.40nMAssay Description:Ability to inhibit the binding of [3H]-DAGO to Opioid receptor mu 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetOpioid receptor delta 1(Bovine)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  9.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2011
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  10.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetMu-type opioid receptor(Bovine)
Stanford University

Curated by PDSP Ki Database
LigandPNGBDBM21025([D-Ala2-D-Leu5]enkephalin | (D-Ala2,D-Leu5)-Enkeph...)
Affinity DataKi:  14.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2011
Entry Details
PubMed
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