BDBM50143313 (12S,13aS)-12-Methoxy-1,4,5,6,9,11,12,13-octahydro-8H-pyrano[4',3':3,4]pyrido[2,1-i]indol-2-one::CHEMBL293950::DHbetaE

SMILES CO[C@H]1CC=C2CCN3[C@]2(C1)C4=C(CC3)COC(=O)C4

InChI Key InChIKey=ALSKYCOJJPXPFS-UHFFFAOYSA-N

Data  12 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50143313   

TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataIC50: 3.70nMAssay Description:Blockage of Nicotinic acetylcholine receptor alpha4-beta2 noncompetitively in cultured hippocampal neuronsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at rat alpha3beta4 nAChR transfected in HEK293 cells by FLIPR membrane potential blue (FMP) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit beta-2(Mouse)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at mouse alpha4beta2 nAChR transfected in HEK293 cells by FLIPR membrane potential blue (FMP) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Illinois Chicago

Curated by ChEMBL
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataIC50: 880nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNicotinic acetylcholine receptor(Cape York rat)
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataKi:  130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataKi:  140nMAssay Description:Inhibition of rat membrane alpha4beta2 nAChR by [3H]cytisine binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataKi:  600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataKi:  820nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR transfected in HEK293 cells after 4 hrs by scintillation count analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataKi:  3.80E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataKi:  6.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Barrow Neurological Institute

Curated by PDSP Ki Database
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rat)
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rat)
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataKi:  1.00E+5nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nAChR transfected in HEK293 cells after 4 hrs by scintillation count analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50143313(CHEMBL293950 | DHbetaE | (12S,13aS)-12-Methoxy-1,4...)
Affinity DataKi:  1.00E+5nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR transfected in HEK293 cells after 4 hrs by scintillation count analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed