BDBM517694 ESI-09::US11124489, Entry 5

SMILES CC(C)(C)c1ccc(cc1)C(=O)C(NNc1ccccc1)C#N

InChI Key InChIKey=XHJCKFFRUFGZEM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 517694   

TargetRap guanine nucleotide exchange factor 4(Human)
University Of Texas

US Patent
LigandPNGBDBM517694(ESI-09 | US11124489, Entry 5)
Affinity DataIC50: 4.40E+3nMAssay Description:From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetRap guanine nucleotide exchange factor 3(Human)
University Of Texas

US Patent
LigandPNGBDBM517694(ESI-09 | US11124489, Entry 5)
Affinity DataIC50: 1.08E+4nMAssay Description:To explore the SARs and examine how the modifications on the isoxazole ring affect biological activities of newly synthesized analogues, we first eva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent