BDBM50606586 DAPRODUSTAT::Daprodustat::GSK-1278863::GSK1278863

SMILES OC(=O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C2CCCCC2)C1=O

InChI Key InChIKey=RUEYEZADQJCKGV-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50606586   

TargetEgl nine homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606586BDBM50606586(DAPRODUSTAT | Daprodustat | GSK-1278863 | GSK12788...)
Affinity DataIC50: 67nMAssay Description:Inhibition of N-terminal His tagged PHD2 (181 to 426 residues) (unknown origin) measured by MALDI-TOF MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetEgl nine homolog 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606586BDBM50606586(DAPRODUSTAT | Daprodustat | GSK-1278863 | GSK12788...)
Affinity DataIC50: 180nMAssay Description:Inhibition of PHD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetBifunctional peptidase and arginyl-hydroxylase JMJD5(Homo sapiens)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606586BDBM50606586(DAPRODUSTAT | Daprodustat | GSK-1278863 | GSK12788...)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of N-terminal His6-thioredoxin-tagged full-length recombinant human JMJD5 (1 to 416 residues) extracted from Escherichia coli BL21(DE3) us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetAspartyl/asparaginyl beta-hydroxylase(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606586BDBM50606586(DAPRODUSTAT | Daprodustat | GSK-1278863 | GSK12788...)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of AspH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGamma-butyrobetaine dioxygenase(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606586BDBM50606586(DAPRODUSTAT | Daprodustat | GSK-1278863 | GSK12788...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of full-length recombinant human BBOX using GBB/2-OG as substrate preincubated for 15 mins followed by substrate addition measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606586BDBM50606586(DAPRODUSTAT | Daprodustat | GSK-1278863 | GSK12788...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of FIH (unknown origin) by solid-phase extraction coupled to MS based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetLysine-specific demethylase 4A(Human)
University of Oxford

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606586BDBM50606586(DAPRODUSTAT | Daprodustat | GSK-1278863 | GSK12788...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of KDM4A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed