BDBM50543359 GSK620

SMILES CNC(=O)C1=CC(=CN(C1=O)Cc2ccccc2)C(=O)NC3CC3

InChI Key InChIKey=QZZCUOVXHPAQRQ-UHFFFAOYSA-N

Data  21 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50543359   

TargetBromodomain-containing protein 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 1.58E+4nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from His6-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant (unknown origin) after 30 mins by TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 81nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 1.74E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 79nMAssay Description:Inhibition of BRD4 BD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of BRD4 BD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 3(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 72nMAssay Description:Inhibition of BRD3-BD2 (unknown origin) assessed as dissociation constant by TR-FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of BRD3-BD1 (unknown origin) assessed as dissociation constant by TR-FRET methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 79nMAssay Description:Inhibition of 6His-Thr-BRD4 (1 to 477 residues) BD1 domain (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of 6His-Thr-BRD4 (1 to 477 residues) BD2 domain Y390A mutant (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 79nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from 6His-Thr tagged BRD4 BD2/BD1 Y97A mutant (1 to 477 residue) (unknown origin) measured after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 1.58E+4nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from 6His-Thr tagged BRD4 BD1/BD2 Y390A mutant (1 to 477 residue) (unknown origin) measured after 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 79nMAssay Description:Binding affinity to 6His-Thr-BRD4 (1 to 477 residues) BD2 domain Y390A mutant (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 79nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from His6-tagged BRD4 BD2 (1 to 477 residues)/BD1 Y97A mutant (unknown origin) after 30 mins by TR-FR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBile salt export pump(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of BSEP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of CYP3A4 (unknown origin) by Cyprotex-protocol assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 3.98E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 2.51E+4nMAssay Description:Binding affinity to 6His-FLAG-Tev-BRDT (1 to 397 residues) BD1 domain (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 2.51E+4nMAssay Description:Binding affinity to 6His-Thr-BRD3 (1 to 435 residues) BD1 domain (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 2.51E+4nMAssay Description:Binding affinity to 6His-Thr-BRD2 (1 to 473 residues) BD1 domain (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50543359(GSK620)
Affinity DataIC50: 1.58E+4nMAssay Description:Binding affinity to 6His-Thr-BRD4 (1 to 477 residues) BD1 domain (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)