BDBM50571531 Gs 441524::Gs-441524::Gs441524::US20240140975, Compound GS-441524::US20240166680, Compound GS-441524

SMILES c1cc(n2c1c(ncn2)N)[C@]3([C@@H]([C@@H]([C@H](O3)CO)O)O)C#N

InChI Key InChIKey=BRDWIEOJOWJCLU-UHFFFAOYSA-N

Data  1 IC50  7 EC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50571531   

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50571531(Gs 441524 | Gs-441524 | Gs441524 | US20240140975, ...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of HCV NS5B RNA-dependent RNA polymerase using sshRNA template preincubated for 5 mins followed by compound addition and measured after 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM50571531(Gs 441524 | Gs-441524 | Gs441524 | US20240140975, ...)
Affinity DataEC50:  460nMAssay Description:Determination of the inhibitory activity of compounds on the replication of 2019 novel coronavirus (SARS-CoV-2): anti-novel coronavirus activity test...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2024
Entry Details
Go to US Patent

TargetSpike glycoprotein(HCoV-OC43)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM50571531(Gs 441524 | Gs-441524 | Gs441524 | US20240140975, ...)
Affinity DataEC50:  1.77E+3nMAssay Description:Determination of the inhibitory activity of compounds on the replication of 2019 novel coronavirus (SARS-CoV-2): anti-novel coronavirus activity test...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2024
Entry Details
Go to US Patent

TargetSpike glycoprotein(2019-nCoV)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM50571531(Gs 441524 | Gs-441524 | Gs441524 | US20240140975, ...)
Affinity DataEC50:  470nMAssay Description:Determination of the inhibitory activity of compounds on the replication of 2019 novel coronavirus (SARS-CoV-2): anti-novel coronavirus activity test...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2024
Entry Details
Go to US Patent

TargetSpike glycoprotein(HCoV-OC43)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM50571531(Gs 441524 | Gs-441524 | Gs441524 | US20240140975, ...)
Affinity DataEC50:  1.88E+3nMAssay Description:Determination of the inhibitory activity of compounds on the replication of 2019 novel coronavirus (SARS-CoV-2): anti-novel coronavirus activity test...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2024
Entry Details
Go to US Patent

TargetReplicase polyprotein 1a(2019-nCoV)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM50571531(Gs 441524 | Gs-441524 | Gs441524 | US20240140975, ...)
Affinity DataEC50:  440nMAssay Description:Determining the inhibitory activity of compounds of the present invention on the replication of 2019 novel coronavirus (SARS-CoV-2): Vero E6 cells we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
Go to US Patent

TargetReplicase polyprotein 1a(2019-nCoV)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM50571531(Gs 441524 | Gs-441524 | Gs441524 | US20240140975, ...)
Affinity DataEC50:  430nMAssay Description:Determining the inhibitory activity of compounds of the present invention on the replication of 2019 novel coronavirus (SARS-CoV-2): Vero E6 cells we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
Go to US Patent

TargetReplicase polyprotein 1a(2019-nCoV)
Shanghai Institute of Materia Medica

US Patent
LigandPNGBDBM50571531(Gs 441524 | Gs-441524 | Gs441524 | US20240140975, ...)
Affinity DataEC50:  480nMAssay Description:Determining the inhibitory activity of compounds of the present invention on the replication of 2019 novel coronavirus (SARS-CoV-2): Vero E6 cells we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
Go to US Patent