BDBM50017811 CHEMBL467::HU::US10155732, Compound HU::hydroxyurea

SMILES C(=O)(N)NO

InChI Key InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N

Data  4 KI  6 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50017811   

TargetStromelysin-1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | US10155732, Compound HU | HU | hydroxy...)
Affinity DataKd: >2.50E+7nMAssay Description:Binding to stromelysin (MMP-3) in place of acetohydroxamic acid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50017811(CHEMBL467 | US10155732, Compound HU | HU | hydroxy...)
Affinity DataIC50: 1.48E+5nMAssay Description:A diverse compound library from NCI Developmental Therapeutics Program (DTP) was subjected to a virtual screening process to identify potential RR in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
Go to US Patent

TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | US10155732, Compound HU | HU | hydroxy...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50017811(CHEMBL467 | US10155732, Compound HU | HU | hydroxy...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50017811(CHEMBL467 | US10155732, Compound HU | HU | hydroxy...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50017811(CHEMBL467 | US10155732, Compound HU | HU | hydroxy...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetRibonucleoside-diphosphate reductase large subunit(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | US10155732, Compound HU | HU | hydroxy...)
Affinity DataIC50: 9.97E+5nMAssay Description:Inhibition of human ribonucleotide reductase M1 subunit expressed in Escherichia coli BL21 (DE3) using 14C-ADP as substrate by liquid scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | US10155732, Compound HU | HU | hydroxy...)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of human CA9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | US10155732, Compound HU | HU | hydroxy...)
Affinity DataKi:  2.80E+4nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | US10155732, Compound HU | HU | hydroxy...)
Affinity DataKi:  3.10E+4nMAssay Description:Inhibition of human CA5aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50017811(CHEMBL467 | US10155732, Compound HU | HU | hydroxy...)
Affinity DataKi:  1.13E+5nMAssay Description:Inhibition of human CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed