BDBM50649855 HMPL-012::Hmpl-012::Sulfatinib::Surufatinib

SMILES Cc1cc2cc(Oc3ccnc(Nc4cccc(CS(=O)(=O)NCCN(C)C)c4)n3)ccc2[nH]1

InChI Key InChIKey=TTZSNFLLYPYKIL-UHFFFAOYSA-N

Data  14 IC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50649855   

TargetTyrosine-protein kinase Mer(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetVascular endothelial growth factor receptor 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 1nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 1nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
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TargetVascular endothelial growth factor receptor 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 1nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 67nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
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TargetFibroblast growth factor receptor 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 15nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetBDNF/NT-3 growth factors receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 41nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
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TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 79nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetVascular endothelial growth factor receptor 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 2nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 24nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetVascular endothelial growth factor receptor 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 1nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetFibroblast growth factor receptor 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 15nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMedPDB3D Structure (crystal)
Copy Rxn URL

TargetBDNF/NT-3 growth factors receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 41nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL

LigandBDBM50649855(Surufatinib | Hmpl-012 | Sulfatinib | HMPL-012)Copy SMILESCopy InChI

Affinity DataIC50: 67nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPDB

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL