BDBM50061220 1-((S)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-m-tolyl-urea::1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-m-tolyl-urea::1-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-m-tolyl-urea((S)L365_260)::CHEMBL70380::L-365,260

SMILES CN1c2ccccc2C(=N[C@H](NC(=O)Nc2cccc(C)c2)C1=O)c1ccccc1

InChI Key InChIKey=KDFQABSFVYLGPM-UHFFFAOYSA-N

Data  17 KI  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50061220   

TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataIC50: 130nMAssay Description:Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Mouse)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataIC50: 150nMAssay Description:Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataIC50: 3nMAssay Description:Half maximal inhibition of specific binding of [125I]-Bolton-Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataIC50: 150nMpH: 6.5Assay Description:The compound was tested for its activity to inhibit the binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetCholecystokinin receptor type A(Rat)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataIC50: 3nMAssay Description:The compound was tested for its activity to inhibit the binding of [3H]-L-364,718 to Cholecystokinin type A receptor in rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataIC50: 151nMAssay Description:Half maximal inhibition of binding of [125I]CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of binding of [125I]CCK-8 to cholecystokinin type A receptor in rat pancreatic tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataIC50: 280nMAssay Description:Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataIC50: 3nMAssay Description:Displacement of [125 I] CCK-8 from Cholecystokinin type A receptor of rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataIC50: 151nMAssay Description:Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetCholecystokinin(Pig)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Mouse)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetCholecystokinin(Pig)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetCholecystokinin(Pig)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  2.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  3.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetCholecystokinin(Pig)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  4.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2011
Entry Details
PubMed
TargetCholecystokinin(Pig)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  7.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2011
Entry Details
PubMed
TargetCholecystokinin(Pig)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  8.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details
PubMed
TargetGastrin/cholecystokinin type B receptor(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  19nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetGastrin/cholecystokinin type B receptor(Dog)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  23nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Dog)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  39nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetCholecystokinin(Pig)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  280nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Dog)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  1.10E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Mouse)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  1.50E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50061220(CHEMBL70380 | L-365,260 | 1-(1-Methyl-2-oxo-5-phen...)
Affinity DataKi:  5.40E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed