BDBM50375588 CHEMBL258818::LCAGLY

SMILES C[C@H](CCC(=O)NCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI Key InChIKey=XBSQTYHEGZTYJE-UHFFFAOYSA-N

Data  6 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50375588   

TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Human)
Jagiellonian University

LigandPNGBDBM50375588(CHEMBL258818 | LCAGLY)
Affinity DataIC50: 5.00E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2017
Entry Details Article
PubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Human)
Jagiellonian University

LigandPNGBDBM50375588(CHEMBL258818 | LCAGLY)
Affinity DataIC50: 5.00E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2017
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM50375588(CHEMBL258818 | LCAGLY)
Affinity DataIC50: 1.38E+5nMAssay Description:Antagonist activity at EphA2 in human PC3 cells assessed as inhibition of ephrin-A1-Fc-stimulated EphA2 phosphorylation pretreated for 20 mins by san...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
University of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50375588(CHEMBL258818 | LCAGLY)
Affinity DataIC50: 5.00E+4nMAssay Description:Antagonist activity against VP16 tagged-VDR-LBD (unknown origin) expressed in HEK293T cells assessed as inhibition of 1,25-dihydroxyvitamin D3-induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
University of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50375588(CHEMBL258818 | LCAGLY)
Affinity DataIC50: 4.01E+4nMAssay Description:Antagonist activity against VDR-LBD (unknown origin) expressed in Escherichia coli assessed as inhibition of VDR agonist LG190178-induced SRC2-3 coac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
University of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50375588(CHEMBL258818 | LCAGLY)
Affinity DataEC50: >1.50E+5nMAssay Description:Agonist activity at VP16 tagged-VDR-LBD (unknown origin) expressed in HEK293T cells assessed as SRC1 coactivator peptide recruitment after 16 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
University of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50375588(CHEMBL258818 | LCAGLY)
Affinity DataEC50: >1.50E+5nMAssay Description:Agonist activity at VDR-LBD (unknown origin) expressed in Escherichia coli assessed as SRC2-3 coactivator peptide recruitment after 30 mins by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
University of Parma

Curated by ChEMBL
LigandPNGBDBM50375588(CHEMBL258818 | LCAGLY)
Affinity DataIC50: 1.38E+5nMAssay Description:Antagonist activity at EphA2 receptor in human PC3 cells assessed as inhibition of ephrin-A1-Fc-stimulated cell retraction pretreated for 15 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Centre National de la Recherche Scientifique/INSERM/ULP

Curated by ChEMBL
LigandPNGBDBM50375588(CHEMBL258818 | LCAGLY)
Affinity DataEC50:  540nMAssay Description:Agonist activity at human TGR5 expressed in CHO cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed