BDBM36332 LI-1::Legumain Inhibitor -1

SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)N(CC(N)=O)NC(=O)[C@@H]1CCCN1C(C)=O

InChI Key InChIKey=TZKVALJHLJILLI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 36332   

TargetLegumain(Mouse)
Stanford University

LigandPNGBDBM36332(LI-1 | Legumain Inhibitor -1)
Affinity DataIC50: 11.5nMpH: 5.8 T: 2°CAssay Description:IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2011
Entry Details Article
PubMed
TargetCathepsin B(Mouse)
Stanford University

LigandPNGBDBM36332(LI-1 | Legumain Inhibitor -1)
Affinity DataIC50: 3.90E+5nMpH: 6.25 T: 2°CAssay Description:IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2011
Entry Details Article
PubMed
TargetProcathepsin L(Mouse)
Stanford University

LigandPNGBDBM36332(LI-1 | Legumain Inhibitor -1)
Affinity DataIC50: 2.20E+5nMpH: 6.25 T: 2°CAssay Description:IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2011
Entry Details Article
PubMed
TargetCaspase-3(Mouse)
Stanford University

LigandPNGBDBM36332(LI-1 | Legumain Inhibitor -1)
Affinity DataIC50: 8.90E+5nMpH: 7.4 T: 2°CAssay Description:IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2011
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University

LigandPNGBDBM36332(LI-1 | Legumain Inhibitor -1)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed