BDBM50026952 (cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmethyl]-dimethyl-amine(LR 5182)::CHEMBL322067::LR 5182::[(2R,3S)-3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmethyl]-dimethyl-amine

SMILES CN(C)C[C@@H]1C2CCC(CC2)[C@@H]1c1ccc(Cl)c(Cl)c1

InChI Key

Data  10 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50026952   

TargetSodium-dependent noradrenaline transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataIC50: 22nMAssay Description:In vitro inhibition of [3H]NE re-uptake into synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataIC50: 270nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataIC50: 28nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataIC50: 51nMAssay Description:Effect on synaptosomal uptake inhibition of 5-hydroxytryptamine (5-HT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataIC50: 5.40nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataIC50: 9.30nMAssay Description:Effect of compound on synaptosomal uptake inhibition of Dopamine (DA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Lundbeck Ais

Curated by PDSP Ki Database
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataKi:  5.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataKi:  7.20nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataKi:  9.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataKi:  44nMAssay Description:Compound was tested for its ability to displace [3H]citalopram from norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataKi:  51nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Lundbeck Ais

Curated by PDSP Ki Database
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataKi:  570nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Lundbeck Ais

Curated by PDSP Ki Database
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Lundbeck Ais

Curated by PDSP Ki Database
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50026952(CHEMBL322067 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bi...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed