BDBM50066066 (S)-1-[4-(Benzothiazol-2-yl-methyl-amino)-piperidin-1-yl]-3-(3,4-difluoro-phenoxy)-propan-2-ol::1-[4-(Benzothiazol-2-yl-methyl-amino)-piperidin-1-yl]-3-(3,4-difluoro-phenoxy)-propan-2-ol(Lubeluzole)::CHEMBL281724::LUBELUZOLE

SMILES CN(C1CCN(C[C@H](O)COc2ccc(F)c(F)c2)CC1)c1nc2ccccc2s1

InChI Key InChIKey=OZFSWVOEXHGDES-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50066066   

TargetCalmodulin(Bovine)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50066066(CHEMBL281724 | (S)-1-[4-(Benzothiazol-2-yl-methyl-...)
Affinity DataKd:  2.90E+3nMAssay Description:Binding affinity to bovine brain CaM by FTPFACE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2017
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Rat)
Cambridge Neuroscience

Curated by ChEMBL
LigandPNGBDBM50066066(CHEMBL281724 | (S)-1-[4-(Benzothiazol-2-yl-methyl-...)
Affinity DataIC50: 260nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50066066(CHEMBL281724 | (S)-1-[4-(Benzothiazol-2-yl-methyl-...)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibitory effect against veratridine-induced glutamate release from rat brain slicesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rat)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM50066066(CHEMBL281724 | (S)-1-[4-(Benzothiazol-2-yl-methyl-...)
Affinity DataKi:  203nMAssay Description:Displacement of [3H]BTX from sodium channel of rat cerebral cortex synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed