BDBM50368782 Bexlosteride::CHEMBL24955::LY-191704

SMILES CN1[C@@H]2CCc3cc(Cl)ccc3[C@H]2CCC1=O

InChI Key InChIKey=WQBIOEFDDDEARX-UHFFFAOYSA-N

Data  6 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50368782   

Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataIC50: 8nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for inhibition of Type II 5-alpha-reductase in Human Prostate Homogenates (HPH)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of recombinant human Steroid 5-alpha-reductase type 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of recombinant human Steroid 5-alpha-reductase type IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of type 2 steroid-5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of type 1 steroid-5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataIC50: 2.30nMAssay Description:Inhibitory activity against Steroid 5-alpha-reductase type I in human scalp homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataKi:  4nMAssay Description:In vitro inhibition of recombinant human Steroid 5-alpha-reductase type IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article

Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataKi:  4nMAssay Description:In vitro inhibition of recombinant human Steroid 5-alpha-reductase type IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article

LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataKi:  8nMAssay Description:Binding affinity on rat 5-alpha reductase-1 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataKi:  1.00E+3nMAssay Description:In vitro inhibition of recombinant human Steroid 5-alpha-reductase type 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article

Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataKi:  1.00E+3nMAssay Description:In vitro inhibition of recombinant human Steroid 5-alpha-reductase type 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article

LigandPNGBDBM50368782(Bexlosteride | LY-191704 | CHEMBL24955)
Affinity DataKi:  1.00E+4nMAssay Description:Binding affinity on rat 5-alpha reductase-2 isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed