BDBM50045775 (3R,4R)3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol::3-((3R,4R)-1-((S)-3-cyclohexyl-3-hydroxypropyl)-3,4-dimethylpiperidin-4-yl)phenol::3-[(3R,4R)-1-((S)-3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol::3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol::CHEMBL300662::LY-255582

SMILES C[C@H]1CN(CC[C@H](O)C2CCCCC2)CC[C@@]1(C)c1cccc(O)c1

InChI Key InChIKey=LVVHEFJXPXAUDD-UHFFFAOYSA-N

Data  24 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50045775   

LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Tested for affinity against alpha-adrenergic using [3H]WB-4101 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Tested for affinity against alpha-2-adrenergic using [3H]clonidine in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Tested for affinity against dopamine autoreceptor using [3H]apomorphine in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Tested for affinity against dopamine D2 receptor using [3H]SCH-23390 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Tested for affinity against muscarinic acetylcholine using [3H]quinuclidinyl benzylate in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Tested for affinity against dopamine D1 receptor using [3H]SCH-23,390 in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Tested for affinity against beta-adrenergic using [3H]dihydroalprenolol in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  0.0210nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]GTP-gamma-S, binding to Opioid receptor mu 1 in Guinea pig caudate st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  0.0430nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]diprenorphine from cloned human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  0.150nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  0.312nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]GTP-gamma-S, binding in Guinea pig caudate stimulated by SMC-80 (Opio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  0.320nMAssay Description:Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 of rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  0.320nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  0.320nMAssay Description:Inhibition of binding of [3H]DAMGO to Opioid receptor mu 1 in guinea pig membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  0.330nMAssay Description:The compound was tested for antagonist activity by selective inhibition of [35S]GTP-gamma-S, binding in Guinea pig caudate stimulated by U69,593 to O...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  0.410nMAssay Description:Binding affinity towards mu-opioid receptor by the displacement of [3H]Nal in rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human delta opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards kappa opioid receptor by displacement of [3H]EKC in guinea pig cortical tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity to human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]diprenorphine from cloned human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cells in presence of high sodium by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]bremazocine from human delta opioid receptor expressed in CHO cells in presence of high sodium by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]bremazocine from cloned human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity towards delta-opioid receptor by displacement of [3H]DADL in rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  28nMAssay Description:Inhibition of binding of [3H]U69, 593 to Opioid receptor kappa 1 in guinea pig membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  28nMAssay Description:Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1 of guinea pig membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  198nMAssay Description:Inhibition of binding of [3H]DADLE to Opioid receptor delta 1 in guinea pig membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50045775(3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-...)
Affinity DataKi:  198nMAssay Description:Inhibition of [3H]-DADLE binding to Opioid receptor delta 1 of rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed