BDBM50213272 CHEBI:6426::Leupeptin

SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O

InChI Key InChIKey=GDBQQVLCIARPGH-UHFFFAOYSA-N

Data  2 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50213272   

TargetCathepsin B(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50213272(CHEBI:6426 | Leupeptin)
Affinity DataIC50: 21.6nMAssay Description:Inhibitory activity against Cathepsin B was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2018
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50213272(CHEBI:6426 | Leupeptin)
Affinity DataIC50: 300nMAssay Description:In vitro inhibitory activity against human erythrocyte Calpain 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCathepsin B(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50213272(CHEBI:6426 | Leupeptin)
Affinity DataIC50: 117nMAssay Description:Compound was tested for its inhibitory activity against cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetCathepsin K(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50213272(CHEBI:6426 | Leupeptin)
Affinity DataIC50: 42.2nMAssay Description:Inhibition of human Cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetPapain(Papaya)
University of Applied Sciences of Darmstadt

Curated by ChEMBL
LigandPNGBDBM50213272(CHEBI:6426 | Leupeptin)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of papaya papain using cbzFRamc substrate preincubated for 10 mins followed by addition of substrate and measured every 30 sec for 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetTrypsin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50213272(CHEBI:6426 | Leupeptin)
Affinity DataIC50: 600nMAssay Description:Inhibition of trypsin (unknown origin) using Nalpha-benzoyl-D/L-arginine-4-nitroanilide hydrochloride as substrate preincubated for 5 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCathepsin B(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50213272(CHEBI:6426 | Leupeptin)
Affinity DataKi:  5nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCathepsin K(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50213272(CHEBI:6426 | Leupeptin)
Affinity DataKi:  24nMAssay Description:Competitive inhibition of recombinant human cathepsin K expressed in Pichia pastoris using Z-FR-MCA as substrate by Dixon plot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2019
Entry Details Article
PubMed