BDBM50007102 6,11-Dimethyl-3-(tetrahydro-furan-2-ylmethyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol::CHEMBL79470::MR-2034

SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2C[C@@H]1CCCO1

InChI Key

Data  8 KI  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50007102   

TargetKappa-type opioid receptor(Guinea pig)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50007102(CHEMBL79470 | MR-2034 | 6,11-Dimethyl-3-(tetrahydr...)
Affinity DataIC50: 1.70nMAssay Description:Displacement of [3H]bremazocine from opioid receptor kappa of guinea pig membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50007102(CHEMBL79470 | MR-2034 | 6,11-Dimethyl-3-(tetrahydr...)
Affinity DataIC50: 17nMAssay Description:Activity at human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50007102(CHEMBL79470 | MR-2034 | 6,11-Dimethyl-3-(tetrahydr...)
Affinity DataEC50:  4nMAssay Description:Incorporation of [35S]GTP-gamma-S, into CHO membranes expressing human Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50007102(CHEMBL79470 | MR-2034 | 6,11-Dimethyl-3-(tetrahydr...)
Affinity DataEC50:  2.70nMAssay Description:Activity at human cloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50007102(CHEMBL79470 | MR-2034 | 6,11-Dimethyl-3-(tetrahydr...)
Affinity DataEC50:  1nMAssay Description:Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50007102(CHEMBL79470 | MR-2034 | 6,11-Dimethyl-3-(tetrahydr...)
Affinity DataKi:  0.0730nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50007102(CHEMBL79470 | MR-2034 | 6,11-Dimethyl-3-(tetrahydr...)
Affinity DataKi:  0.0730nMAssay Description:Displacement of [3H]U69,593 from KOR in guinea pig brain membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50007102(CHEMBL79470 | MR-2034 | 6,11-Dimethyl-3-(tetrahydr...)
Affinity DataKi:  0.0900nMAssay Description:Displacement of [3H]U69593 form kappa opioid receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50007102(CHEMBL79470 | MR-2034 | 6,11-Dimethyl-3-(tetrahydr...)
Affinity DataKi:  0.170nMAssay Description:Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50007102(CHEMBL79470 | MR-2034 | 6,11-Dimethyl-3-(tetrahydr...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]DAMGO from MOR in guinea pig brain membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50007102(CHEMBL79470 | MR-2034 | 6,11-Dimethyl-3-(tetrahydr...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]DAMGO form mu opioid receptor in guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50007102(CHEMBL79470 | MR-2034 | 6,11-Dimethyl-3-(tetrahydr...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity towards Opioid receptor delta 1 from guinea pig brain using [3H]naltrindole as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOpioid receptor delta 1(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50007102(CHEMBL79470 | MR-2034 | 6,11-Dimethyl-3-(tetrahydr...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]Naltrindole from DOR in guinea pig brain membranes after 3 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed