BDBM50118229 CHEMBL129841::MRS 2179

SMILES CNc1ncnc2n(cnc12)[C@H]1C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O1

InChI Key InChIKey=CCPLITQNIFLYQB-UHFFFAOYSA-N

Data  17 IC50  2 Kd  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50118229   

TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 740nMAssay Description:Inhibition concentration required against human Y203A (EL2) mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 330nMAssay Description:Inhibition of human P2Y1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetP2X purinoceptor 3(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of P2X3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 1(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of P2X1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 2.25E+3nMAssay Description:Antagonist activity at human platelet P2Y1 receptor assessed as inhibition of ADP-induced increase in cytosolic calcium level by FLUO-4 staining base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 330nMAssay Description:Antagonist activity at P2Y1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataKd:  282nMAssay Description:pA2 value was evaluated against P2Y purinoceptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataKd:  109nMAssay Description:Binding affinity to human P2Y1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 660nMAssay Description:Inhibition concentration required against human Y273F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 980nMAssay Description:Inhibition concentration required against human Y306F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 320nMAssay Description:Inhibition concentration required against human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 480nMAssay Description:Inhibition concentration required against human Y273A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radiol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 330nMAssay Description:Inhibition concentration required against human Y203F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 210nMAssay Description:Inhibition concentration required against wild type strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 330nMAssay Description:Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataEC50: >1.00E+4nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 3 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 1(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataEC50:  1.15E+3nMAssay Description:The compound was evaluated for antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 )More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataEC50: >1.00E+5nMAssay Description:The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 2(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataEC50: >1.00E+5nMAssay Description:Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataEC50: >1.00E+5nMAssay Description:The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataEC50: >1.00E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataEC50:  1.30E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 30 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 331nMAssay Description:Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythrocyte ghostsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 1(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 1.15E+3nMAssay Description:Affinity at P2X purinoceptor 1 (P2X1) and the value is expressed as IC50More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
Northwest University

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 1.29E+4nMAssay Description:Affinity at P2X purinoceptor 3 (P2X3) and the value is expressed as IC50More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataIC50: 331nMAssay Description:In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118229(MRS 2179 | CHEMBL129841)
Affinity DataEC50:  330nMAssay Description:Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed