BDBM50156357 2-Hydroxymethyl-1-nonyl-piperidine-3,4,5-triol::CHEMBL187158::NN-DNJ

SMILES CCCCCCCCC[N@@]1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O

InChI Key InChIKey=FTSCEGKYKXESFF-UHFFFAOYSA-N

Data  1 KI  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50156357   

TargetLysosomal acid glucosylceramidase(Human)
Nankai University

LigandPNGBDBM50156357(CHEMBL187158 | NN-DNJ | 2-Hydroxymethyl-1-nonyl-pi...)
Affinity DataIC50: 668nMpH: 7.0Assay Description:The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLysosomal acid glucosylceramidase(Human)
Nankai University

LigandPNGBDBM50156357(CHEMBL187158 | NN-DNJ | 2-Hydroxymethyl-1-nonyl-pi...)
Affinity DataIC50: 979nMpH: 5.2Assay Description:The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPrunasin hydrolase(Almond)
Nankai University

LigandPNGBDBM50156357(CHEMBL187158 | NN-DNJ | 2-Hydroxymethyl-1-nonyl-pi...)
Affinity DataIC50: 9.59E+4nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
TargetOligo-1,6-glucosidase IMA1(Baker's yeast)
Nankai University

LigandPNGBDBM50156357(CHEMBL187158 | NN-DNJ | 2-Hydroxymethyl-1-nonyl-pi...)
Affinity DataIC50: 1.00E+5nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
TargetAlpha-galactosidase(Arabian coffee)
Nankai University

LigandPNGBDBM50156357(CHEMBL187158 | NN-DNJ | 2-Hydroxymethyl-1-nonyl-pi...)
Affinity DataIC50: 9.49E+3nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50156357(CHEMBL187158 | NN-DNJ | 2-Hydroxymethyl-1-nonyl-pi...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of rat intestinal maltase using disaccharideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetBeta-glucosidase(Cherry)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50156357(CHEMBL187158 | NN-DNJ | 2-Hydroxymethyl-1-nonyl-pi...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibitory activity against beta-Glucosidase from sweet almondMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetPutative alpha-glucosidase(Rice)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50156357(CHEMBL187158 | NN-DNJ | 2-Hydroxymethyl-1-nonyl-pi...)
Affinity DataIC50: 80nMAssay Description:Inhibitory activity against alpha-Glucosidase from riceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50156357(CHEMBL187158 | NN-DNJ | 2-Hydroxymethyl-1-nonyl-pi...)
Affinity DataIC50: 230nMAssay Description:Inhibition of rat intestinal isomaltase using disaccharideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetBeta-glucosidase A(Caldocellum saccharolyticum)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50156357(CHEMBL187158 | NN-DNJ | 2-Hydroxymethyl-1-nonyl-pi...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibitory activity against beta-Glucosidase from Caldocellum saccharolyticumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Orleans University

Curated by ChEMBL
LigandPNGBDBM50156357(CHEMBL187158 | NN-DNJ | 2-Hydroxymethyl-1-nonyl-pi...)
Affinity DataIC50: 660nMAssay Description:Inhibition of rat intestinal sucrase using disaccharideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed
TargetNon-lysosomal glucosylceramidase(Human)
University of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50156357(CHEMBL187158 | NN-DNJ | 2-Hydroxymethyl-1-nonyl-pi...)
Affinity DataIC50: 35nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Nankai University

LigandPNGBDBM50156357(CHEMBL187158 | NN-DNJ | 2-Hydroxymethyl-1-nonyl-pi...)
Affinity DataKi:  488nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)