BDBM50072228 3-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3-yl]-1-aza-bicyclo[2.2.2]octane::CHEMBL99521::NNC 11-1314

SMILES C(Oc1nsnc1C1CN2CCC1CC2)C#Cc1ccccc1

InChI Key InChIKey=SNSMIIQEKVYNOH-UHFFFAOYSA-N

Data  5 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50072228   

TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50072228(CHEMBL99521 | NNC 11-1314 | 3-[4-(3-Phenyl-prop-2-...)
Affinity DataEC50:  16nMAssay Description:Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50072228(CHEMBL99521 | NNC 11-1314 | 3-[4-(3-Phenyl-prop-2-...)
Affinity DataEC50:  62nMAssay Description:Stimulation of cAMP in CHO cells expressing human m2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50072228(CHEMBL99521 | NNC 11-1314 | 3-[4-(3-Phenyl-prop-2-...)
Affinity DataIC50: 4.70nMAssay Description:Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of Melbourne

Curated by PDSP Ki Database
LigandPNGBDBM50072228(CHEMBL99521 | NNC 11-1314 | 3-[4-(3-Phenyl-prop-2-...)
Affinity DataKi:  14.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50072228(CHEMBL99521 | NNC 11-1314 | 3-[4-(3-Phenyl-prop-2-...)
Affinity DataKi:  41.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Melbourne

Curated by PDSP Ki Database
LigandPNGBDBM50072228(CHEMBL99521 | NNC 11-1314 | 3-[4-(3-Phenyl-prop-2-...)
Affinity DataKi:  49nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50072228(CHEMBL99521 | NNC 11-1314 | 3-[4-(3-Phenyl-prop-2-...)
Affinity DataKi:  58.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
University of Melbourne

Curated by PDSP Ki Database
LigandPNGBDBM50072228(CHEMBL99521 | NNC 11-1314 | 3-[4-(3-Phenyl-prop-2-...)
Affinity DataKi:  77.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMed