BDBM86180 CAS_87075-17-0::NSC_5018::SCH 23390::SCH23390::US9359372, SCH23390

SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)c1ccccc1

InChI Key InChIKey=GOTMKOSCLKVOGG-UHFFFAOYSA-N

Data  10 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 86180   

TargetD(1A) dopamine receptor(Human)
Fudan University

LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataIC50: 520nMpH: 7.5Assay Description:The [35S]GTPγS binding assay was performed at 30 °C for 30 min containing 10 μgof membrane protein in a final volume of 100 μL with va...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Fudan University

LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataIC50: 740nMpH: 7.5Assay Description:For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetD(1B) dopamine receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataIC50: 0.560nMAssay Description:Displacement of [3H]SCH23390 from human recombinant Dopamine D5 receptor expressed in GH4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Fudan University

LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataIC50: 0.310nMAssay Description:Displacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataIC50: 0.560nMAssay Description:Displacement of [3H]SCH 23390 from human recombinant D5 receptor expressed in GH4 cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Fudan University

LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataIC50: 0.310nMAssay Description:Displacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataKi:  0.320nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataKi:  0.690nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Rat)
Purdue University

Curated by PDSP Ki Database
LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Fudan University

LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataKi:  1.24nM ΔG°:  -12.3kcal/mole IC50: 2.52nMT: 2°CAssay Description:Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetD(1A) dopamine receptor(Human)
Fudan University

LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataKi:  1.69nMAssay Description:The transfection of plasmid and membrane preparations was conducted as described in our previous report, with 0.7 nm [3H] SCH23390 (D1R) or [3H]Spipe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataKi:  10.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataKi:  208nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataKi:  1.21E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM86180(NSC_5018 | CAS_87075-17-0 | SCH 23390 | SCH23390 |...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed