BDBM50004178 Nociceptin::Nociceptin/orphanin FQ::ORPHANIN FQ
SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O
InChI Key InChIKey=PULGYDLMFSFVBL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 44 hits for monomerid = 50004178
Affinity DataKd: 0.190nMAssay Description:Binding affinity to human ORL1 receptor expressed in African green monkey COS7 cells assessed per mg protein after 90 mins by Scatchard plot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Displacement of [3H]nociceptin from human recombinant Nociceptin receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
Affinity DataEC50: 0.389nMAssay Description:Antagonist activity at human recombinant NOP receptor expressed in CHO cells coexpressing alphaqi5 assessed as inhibition of N/OFQ-induced intracellu...More data for this Ligand-Target Pair
Affinity DataEC50: 63nMAssay Description:Effective concentration required to stimulate binding of GTPgammaS to Opioid receptor like 1 was determined using scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding against human Opioid receptor like 1More data for this Ligand-Target Pair
Affinity DataEC50: 0.230nMAssay Description:Agonist activity at human nociceptin receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production preincubated f...More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist potency against GTPgammaS binding in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0840nMAssay Description:Displacement of [3H]]isoVa-RYYRIK-NH2 from human ORL1 receptor high affinity binding site expressed in African green monkey COS7 cells after 90 mins ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0900nMAssay Description:Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1More data for this Ligand-Target Pair
Affinity DataEC50: 0.115nMAssay Description:Inhibition of forskolin stimulated cAMP levels in CHO cell membranes expressing the human NOP receptor (CHOhNOP)More data for this Ligand-Target Pair
Affinity DataEC50: 5.40nMAssay Description:Inhibition of electrically evoked contraction of mouse vas deferensMore data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Partial agonist activity at human KOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillatio...More data for this Ligand-Target Pair
Affinity DataEC50: 5.20nMAssay Description:Inhibition of electrically evoked contraction of guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataEC50: 0.427nMAssay Description:Agonist activity at human NOP receptor expressed in CHO cells assessed as dynamic mass redistribution by DMR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 8.10nMAssay Description:Partial agonist activity at human NOP receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintillatio...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Displacement of [3H]]isoVa-RYYRIK-NH2 from human ORL1 receptor low affinity binding site expressed in African green monkey COS7 cells after 90 mins b...More data for this Ligand-Target Pair
Affinity DataEC50: 3.60nMAssay Description:Agonist activity at human nociceptin opioid receptor transfected in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Displacement of [3H]]nociceptin from human ORL1 receptor expressed in African green monkey COS7 cells after 90 mins by topcount analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.00130nMAssay Description:Displacement of [3H]nociceptin from human recombinant NOP receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.0490nMAssay Description:Binding affinity for recombinant human N/OFQ peptide receptor (NOP) expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Binding affinity for opioid receptor like type, human Opioid receptor like 1 expressed in membrane homogenates of COS-1 or CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Displacement of [3H]N/OFQ from human nociceptin opioid receptor transfected in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.180nMAssay Description:Inhibition of [3H]nociceptin binding to human Opioid receptor like 1More data for this Ligand-Target Pair
Affinity DataKi: 0.214nMAssay Description:Displacement of [3H]-nociceptin from human recombinant NOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.390nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells after 45 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.390nMAssay Description:Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Displacement of [3H]-Nociceptin from human NOP receptor expressed in CHO-K1 cells assessed as inhibition constant measured for 1 hr by liquid scintil...More data for this Ligand-Target Pair
Affinity DataKi: 147nMAssay Description:Displacement of [3H]U69593 from human KOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 270nMAssay Description:Binding affinity for opioid receptor type, human Opioid receptor mu 1 expressed in membrane homogenates of COS-1 or CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 437nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]enadoline from human KOP receptor expressed in HEK-293 cells after 45 minsMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DPDPE from human DOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]enadoline from human kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DAMGO from human MOP receptor expressed in CHO-K1 cells after 45 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nMAssay Description:Binding affinity for opioid receptor type, human Opioid receptor kappa 1 expressed in membrane homogenates of COS-1 or CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of [3H]naltrindole binding to human Opioid receptor delta 1More data for this Ligand-Target Pair
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of [3H]U-69593 binding to human Opioid receptor kappa 1More data for this Ligand-Target Pair
Affinity DataKi: 2.85E+3nMAssay Description:Displacement of [3H]Cl-DPDPE from human DOP receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 3.00E+3nMAssay Description:Binding affinity for opioid receptor type, human Opioid receptor delta 1 expressed in membrane homogenates of COS-1 or CHO cellsMore data for this Ligand-Target Pair