BDBM50505850 Dapansutrile::OLT-1177::OLT1177

SMILES CS(=O)(=O)CCC#N

InChI Key InChIKey=LQFRYKBDZNPJSW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50505850   

TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50505850(Dapansutrile | OLT-1177 | OLT1177)
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774A.1 cells assessed as reduction in IL-1beta level preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50505850(Dapansutrile | OLT-1177 | OLT1177)
Affinity DataIC50: 100nMAssay Description:Inhibition of NLRP3 in mouse J774A.1 cells infected with FLA-ST assessed as inhibition of LPS- induced IL-1beta production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50505850(Dapansutrile | OLT-1177 | OLT1177)
Affinity DataIC50: 1nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta level incubated for 1 hr followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505850(Dapansutrile | OLT-1177 | OLT1177)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed