BDBM50034263 CHEMBL25438::PD-156707::Sodium; (Z)-2-benzo[1,3]dioxol-5-yl-4-(4-methoxy-phenyl)-4-oxo-3-(3,4,5-trimethoxy-benzyl)-but-2-enoate

SMILES COc1ccc(cc1)C(=O)C(\Cc1cc(OC)c(OC)c(OC)c1)=C(/C([O-])=O)c1ccc2OCOc2c1

InChI Key InChIKey=OFCTYBMKKTVKCR-UHFFFAOYSA-M

Data  5 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50034263   

TargetEndothelin receptor type B(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034263(PD-156707 | Sodium; (Z)-2-benzo[1,3]dioxol-5-yl-4-...)
Affinity DataIC50: 417nMAssay Description:Tested for antagonistic activity against Endothelin B receptor in the humans (CHO expressed).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034263(PD-156707 | Sodium; (Z)-2-benzo[1,3]dioxol-5-yl-4-...)
Affinity DataIC50: 0.310nMAssay Description:Antagonistic activity against human Endothelin A receptor expressed in LtKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM50034263(PD-156707 | Sodium; (Z)-2-benzo[1,3]dioxol-5-yl-4-...)
Affinity DataIC50: 1.30nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Pig)
Merck

Curated by ChEMBL
LigandPNGBDBM50034263(PD-156707 | Sodium; (Z)-2-benzo[1,3]dioxol-5-yl-4-...)
Affinity DataIC50: 340nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to porcine kidney (inner medulla) membranes Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034263(PD-156707 | Sodium; (Z)-2-benzo[1,3]dioxol-5-yl-4-...)
Affinity DataKi:  0.170nMAssay Description:Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034263(PD-156707 | Sodium; (Z)-2-benzo[1,3]dioxol-5-yl-4-...)
Affinity DataKi:  0.170nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034263(PD-156707 | Sodium; (Z)-2-benzo[1,3]dioxol-5-yl-4-...)
Affinity DataKi:  0.380nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEndothelin receptor type B(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034263(PD-156707 | Sodium; (Z)-2-benzo[1,3]dioxol-5-yl-4-...)
Affinity DataKi:  139nMAssay Description:Tested for binding affinity for human Endothelin B receptor by measuring its ability to displace [125I]-ET-3 from chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034263(PD-156707 | Sodium; (Z)-2-benzo[1,3]dioxol-5-yl-4-...)
Affinity DataKi:  139nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed