BDBM50190786 (R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carboxamide::CHEMBL214268::N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide::PHA-543613::PHA543613

SMILES O=C(N[C@H]1CN2CCC1CC2)c1cc2ccoc2cn1

InChI Key InChIKey=IPKZCLGGYKRDES-UHFFFAOYSA-N

Data  7 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50190786   

LigandPNGBDBM50190786(CHEMBL214268 | PHA-543613 | N-[(3R)-1-azabicyclo[2...)
Affinity DataEC50:  4.20nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2012
Entry Details

LigandPNGBDBM50190786(CHEMBL214268 | PHA-543613 | N-[(3R)-1-azabicyclo[2...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of alpha-3-beta-4 nAChR expressed in SHSY5Y cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786(CHEMBL214268 | PHA-543613 | N-[(3R)-1-azabicyclo[2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50190786(CHEMBL214268 | PHA-543613 | N-[(3R)-1-azabicyclo[2...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of alpha-1-beta-1-gamma-delta nAChR expressed in TE671cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50190786(CHEMBL214268 | PHA-543613 | N-[(3R)-1-azabicyclo[2...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in human IMR32 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50190786(CHEMBL214268 | PHA-543613 | N-[(3R)-1-azabicyclo[2...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]MLA from alpha-7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50190786(CHEMBL214268 | PHA-543613 | N-[(3R)-1-azabicyclo[2...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50190786(CHEMBL214268 | PHA-543613 | N-[(3R)-1-azabicyclo[2...)
Affinity DataKi:  511nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50190786(CHEMBL214268 | PHA-543613 | N-[(3R)-1-azabicyclo[2...)
Affinity DataKi:  628nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190786(CHEMBL214268 | PHA-543613 | N-[(3R)-1-azabicyclo[2...)
Affinity DataKi:  630nMAssay Description:Binding affinity to rat 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSoluble acetylcholine receptor(California sea hare)
Uc San Diego

LigandPNGBDBM50190786(CHEMBL214268 | PHA-543613 | N-[(3R)-1-azabicyclo[2...)
Affinity DataKi:  1.50E+4nM ΔG°:  -6.47kcal/molepH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2012
Entry Details