BDBM50531838 Pirazidol::Pirlindole

SMILES Cc1ccc2n3CCNC4CCCc(c34)c2c1

InChI Key InChIKey=IWVRVEIKCBFZNF-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50531838   

TargetTranscriptional enhancer factor TEF-1(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50531838(Pirazidol | Pirlindole)
Affinity DataKd:  1.20E+4nMAssay Description:Binding affinity to TEAD1 (194 to 411 residues) (unknown origin) by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTranscriptional enhancer factor TEF-5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50531838(Pirazidol | Pirlindole)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of Gal4-fused TEAD3 (unknown origin) interaction with YAP expressed in human HeLa cells assessed as basal transcriptional activity level a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTranscriptional enhancer factor TEF-3(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50531838(Pirazidol | Pirlindole)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of Gal4-fused TEAD4 (unknown origin) interaction with YAP expressed in human HeLa cells assessed as basal transcriptional activity level a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTranscriptional enhancer factor TEF-1(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50531838(Pirazidol | Pirlindole)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of Gal4-fused TEAD1 (unknown origin) interaction with YAP expressed in human HeLa cells assessed as basal transcriptional activity level a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50531838(Pirazidol | Pirlindole)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of Gal4-fused TEAD2 (unknown origin) interaction with YAP expressed in human HeLa cells assessed as basal transcriptional activity level a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed