BDBM400807 QL-XII-66::US10000483, Compound I-16

SMILES Cc1ccc(cc1NC(=O)C=C)-n1c2c(ccc1=O)cnc1ccc(\C=C\c3ccccc3)cc21

InChI Key InChIKey=CEJHRMYKGWBHHX-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 400807   

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM400807(QL-XII-66 | US10000483, Compound I-16)
Affinity DataIC50: 27.8nMAssay Description:Purified BMX was mixed with substrate (FAK or Bmxtides), kinase buffer (final 20 mM HEPES, pH 7.5, 10 mM MgCl2, 20 mM β-glycerophosphate, 1 mM d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM400807(QL-XII-66 | US10000483, Compound I-16)
Affinity DataIC50: 105nMAssay Description:DiscoverX binding assays were performed according to published methods (Fabian et al., Nat. Biotechnol. 23, 329-36 (2005); Davis et al., Nat. Biotech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM400807(QL-XII-66 | US10000483, Compound I-16)
Affinity DataIC50: 28nMAssay Description:DiscoverX binding assays were performed according to published methods (Fabian et al., Nat. Biotechnol. 23, 329-36 (2005); Davis et al., Nat. Biotech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
Go to US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM400807(QL-XII-66 | US10000483, Compound I-16)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant full length His-tagged human BMX expressed in baculovirus expression system using poly (4:1 Glu, Tyr) as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM400807(QL-XII-66 | US10000483, Compound I-16)
Affinity DataIC50: 105nMAssay Description:Inhibition of BTK autophosphorylation at Y223 in anti-IgM stimulated human MOLM13 cells after 4 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM400807(QL-XII-66 | US10000483, Compound I-16)
Affinity DataIC50: 5.58E+3nMAssay Description:Inhibition of recombinant GST-tagged human JAK3 expressed in baculovirus expression system using poly (4:1 Glu, Tyr) as substrate preincubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM400807(QL-XII-66 | US10000483, Compound I-16)
Affinity DataIC50: 607nMAssay Description:Inhibition of recombinant full length His-tagged human BLK expressed in baculovirus expression system using poly (4:1 Glu, Tyr) as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2020
Entry Details Article
PubMed