BDBM50609506 DCC-2618::Dcc-2618::Qinlock::RIPRETINIB::Ripretinib

SMILES CCn1c2cc(NC)ncc2cc(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2Br)c1=O

InChI Key InChIKey=CEFJVGZHQAGLHS-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50609506   

TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50609506(Ripretinib | Dcc-2618 | DCC-2618 | Qinlock | RIPRE...)
Affinity DataIC50: 13nMAssay Description:Inhibition of wild type KIT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50609506(Ripretinib | Dcc-2618 | DCC-2618 | Qinlock | RIPRE...)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of KIT T670I mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50609506(Ripretinib | Dcc-2618 | DCC-2618 | Qinlock | RIPRE...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of KIT D816V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50609506(Ripretinib | Dcc-2618 | DCC-2618 | Qinlock | RIPRE...)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of PDGFRalpha D842V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50609506(Ripretinib | Dcc-2618 | DCC-2618 | Qinlock | RIPRE...)
Affinity DataIC50: 31nMAssay Description:Inhibition of KIT V654A mutant (unknown origin) by FRET based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50609506(Ripretinib | Dcc-2618 | DCC-2618 | Qinlock | RIPRE...)
Affinity DataIC50: 15nMAssay Description:Inhibition of KIT (delta560 to 576 residues) deletion mutant autophosphorylation at Y703 in human GIST430 harboring KIT (delta560 to 576 residues) de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50609506(Ripretinib | Dcc-2618 | DCC-2618 | Qinlock | RIPRE...)
Affinity DataIC50: 185nMAssay Description:Inhibition of KIT (delta 560 to 576 residues) deletion/V654A double mutant autophosphorylation at Y703 in human GIST-430/654 harboring KIT (delta 560...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed