BDBM50367916 METHYLTRIENOLONE::Metribolone::R-1881

SMILES C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@]12C

InChI Key InChIKey=CCCIJQPRIXGQOE-UHFFFAOYSA-N

Data  4 KI  8 IC50  10 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50367916   

TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.560nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 283 KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataIC50: 5nMAssay Description:Binding affinity to GST-tagged androgen receptor LBD (unknown origin) incubated for 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataEC50:  0.110nMAssay Description:Modulation of Androgen receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAndrogen receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity to rat Androgen receptor in African green monkey COS-7 cells measured by whole-cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataIC50: 4.60nMAssay Description:Competitive displacement of [3H]R1881 from human AR-LBD expressed in LNCaP cells incubated for 24 hrs by scintillation counting method based radiolig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataIC50: 0.302nMAssay Description:Agonist activity at GAL4 DNA-binding domain fused androgen receptor (unknown origin) ligand binding domain expressed in UAS-bla GripTite 293 cells as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataIC50: 7nMAssay Description:Binding affinity to androgen receptor by fluorescence binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataIC50: 3.09nMAssay Description:Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.600nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.990nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 298 KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  1.51nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 308 KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  1.95nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 310KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataEC50:  0.0130nMAssay Description:Agonist activity at human androgen receptor expressed in mouse C2C12 cells cotransfected with GRE/ARE reporter plasmid assessed as receptor transacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.610nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 273 KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  1.21nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 303 KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.680nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 288 KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.740nMAssay Description:Dissociation constant value of the radiolabeled compound against the androgen receptor 293 KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKd:  0.520nMAssay Description:Dissociation constant for [3H]R-1881 binding to human androgen receptor at 278 KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat AR-mediated reporter gene expression in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetSex hormone-binding globulin(Rat)
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of rat androgen binding protein (rABP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-methyltrienolone from androgen receptor (unknown origin) expressed in HEK293 cell lysate incubated overnight by microbeta scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]-methyltrienolone from progesterone receptor (unknown origin) expressed in HEK293 cell lysate incubated overnight by microbeta sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H]-aldosterone from mineralocorticoid receptor (unknown origin) expressed in HEK293 cell lysate incubated overnight by microbeta sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50367916(Metribolone | R-1881 | METHYLTRIENOLONE)
Affinity DataKi:  9.70nMAssay Description:Displacement of [3H]-dexamethasone from glucocorticoid receptor (unknown origin) expressed in HEK293 cell lysate incubated overnight by microbeta sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed