BDBM10750 (3R)-3-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-inden-5-yl N-ethyl-N-methylcarbamate hydrochloride::Aminoindan deriv. (R)18b::Aminoindan deriv. (R)18b.HCl::N-propargylaminoindan (R)18b.HCl::R-CPAI

SMILES CCN(C)C(=O)Oc1ccc2CC[C@@H](NCC#C)c2c1

InChI Key InChIKey=LHXOCOHMBFOVJS-UHFFFAOYSA-N

Data  2 KI  23 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 10750   

TargetAcetylcholinesterase(Bovine)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 3.03E+4nMAssay Description:Inhibition of bovine AChE after 120 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of recombinant human AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 770nMAssay Description:Inhibition of MAO-A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCholinesterase(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of human BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCholinesterase(Horse)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of equine serum butyrylcholinesterase using butyrylthiocholine as substrate preincubated for 60 mins followed by substrate addition by Ell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 3.18E+4nMAssay Description:Inhibition of human acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition by Ellma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 3.71E+4nMAssay Description:Inhibition of human MAO-BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human MAO-AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of rat brain MAO-B using [14C]-phenylethylamine as substrate preincubated for 60 mins followed by substrate addition and measured after 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of MAO-B in rat brain using [14C]-phenylethylamine as substrate preincubated for 60 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 5.24E+4nMAssay Description:Inhibition of AChE in human erythrocytes preincubated for 60 mins followed by substrate addition by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of MAO-A in rat brain using [14C]-5-hydroxytryptamine creatinine disulfate as substrate preincubated for 60 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 480nMAssay Description:Inhibition of equine BuChE after 120 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 3.71E+4nMAssay Description:Inhibition of human recombinant MAOB assessed as H2O2 production by Amplex Red reagent-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 5.24E+4nMAssay Description:Inhibition of human AchEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of MAOBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of MAOAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Heinrich Heine University D£Sseldorf

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 1.00E+6nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 3.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 1.98E+3nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataIC50: 3.18E+4nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2006
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataKi:  2.13E+5nM ΔG°:  -5.01kcal/molepH: 7.5 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically at 316 nm and 250 nm using kynuramine and benzylamine as substrates, respectively. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2006
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM10750(R-CPAI | Aminoindan deriv. (R)18b.HCl | (3R)-3-(pr...)
Affinity DataKi:  2.27E+5nM ΔG°:  -4.97kcal/molepH: 7.5 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically at 316 nm and 250 nm using kynuramine and benzylamine as substrates, respectively. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2006
Entry Details Article
PubMed