BDBM50132391 4-((R)-6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanol::4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanol::CHEMBL104466::RP-127963

SMILES COc1cc2ncc(N[C@H]3CC[C@H](O)CC3)nc2cc1OC

InChI Key InChIKey=CYVRFHRDWQAJGA-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50132391   

TargetMitogen-activated protein kinase 10/8/9(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132391(RP-127963 | 4-(6,7-Dimethoxy-quinoxalin-2-ylamino)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of JNK, c-Jun N-terminal kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132391(RP-127963 | 4-(6,7-Dimethoxy-quinoxalin-2-ylamino)...)
Affinity DataIC50: 76nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132391(RP-127963 | 4-(6,7-Dimethoxy-quinoxalin-2-ylamino)...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of Insulin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132391(RP-127963 | 4-(6,7-Dimethoxy-quinoxalin-2-ylamino)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Janus kinase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132391(RP-127963 | 4-(6,7-Dimethoxy-quinoxalin-2-ylamino)...)
Affinity DataIC50: 353nMAssay Description:Inhibition of Mitogenesis, PDGF-BB, assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132391(RP-127963 | 4-(6,7-Dimethoxy-quinoxalin-2-ylamino)...)
Affinity DataIC50: 299nMAssay Description:Inhibition of Mitogenesis, PDGF-AA, assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132391(RP-127963 | 4-(6,7-Dimethoxy-quinoxalin-2-ylamino)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Janus kinase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132391(RP-127963 | 4-(6,7-Dimethoxy-quinoxalin-2-ylamino)...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132391(RP-127963 | 4-(6,7-Dimethoxy-quinoxalin-2-ylamino)...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132391(RP-127963 | 4-(6,7-Dimethoxy-quinoxalin-2-ylamino)...)
Affinity DataIC50: 76nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed