BDBM50507186 Ozanimod::RPC-1063::RPC1063

SMILES CC(C)Oc1ccc(cc1C#N)-c1nc(no1)-c1cccc2[C@H](CCc12)NCCO

InChI Key InChIKey=XRVDGNKRPOAQTN-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50507186   

TargetSphingosine 1-phosphate receptor 1(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50507186(Ozanimod | RPC-1063 | RPC1063)
Affinity DataEC50:  0.410nMAssay Description:Agonist activity at S1P1 receptor (unknown origin) after 120 mins in presence of [35S]-GTPgammaS by Topcount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50507186(Ozanimod | RPC-1063 | RPC1063)
Affinity DataEC50:  0.160nMAssay Description:Agonist activity at S1P1 receptor (unknown origin) assessed as reduction in forskolin-induced cAMP accumulation after 4 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50507186(Ozanimod | RPC-1063 | RPC1063)
Affinity DataEC50:  0.160nMAssay Description:Agonist activity at S1P1 (unknown origin) expressed in CHO-K1 cells using CC4-AM as substrate assessed as inhibition of forskolin-induced cAMP accumu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50507186(Ozanimod | RPC-1063 | RPC1063)
Affinity DataEC50:  4.30nMAssay Description:Agonist activity at S1P5 (unknown origin) assessed as stimulation of [35S]GTPgammaS binding incubated for 120 mins in presence of GDP by TopCount sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed