BDBM50127390 CHEMBL51355::RTI-147::[3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-yl]-pyrrolidin-1-yl-methanone

SMILES CN1[C@@H]2CCC1C([C@H](C2)c1ccc(Cl)cc1)C(=O)N1CCCC1

InChI Key

Data  5 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50127390   

TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127390(RTI-147 | CHEMBL51355 | [3-(4-Chloro-phenyl)-8-met...)
Affinity DataIC50: 3.94E+3nMAssay Description:Inhibition of [3H]nisoxetine binding at norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127390(RTI-147 | CHEMBL51355 | [3-(4-Chloro-phenyl)-8-met...)
Affinity DataIC50: 1.24E+4nMAssay Description:Inhibition of [3H]paroxetine binding at serotonin transporter was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127390(RTI-147 | CHEMBL51355 | [3-(4-Chloro-phenyl)-8-met...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of [3H]WIN-35428 binding at dopamine transporter was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127390(RTI-147 | CHEMBL51355 | [3-(4-Chloro-phenyl)-8-met...)
Affinity DataKi:  1.38nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2012
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127390(RTI-147 | CHEMBL51355 | [3-(4-Chloro-phenyl)-8-met...)
Affinity DataKi:  1.13E+3nMAssay Description:Inhibition of [3H]paroxetine binding at serotonin transporter was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127390(RTI-147 | CHEMBL51355 | [3-(4-Chloro-phenyl)-8-met...)
Affinity DataKi:  2.37E+3nMAssay Description:Affinity for norepinephrine transporter determined by [3H]nisoxetine displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM50127390(RTI-147 | CHEMBL51355 | [3-(4-Chloro-phenyl)-8-met...)
Affinity DataKi:  3.95E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2012
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127390(RTI-147 | CHEMBL51355 | [3-(4-Chloro-phenyl)-8-met...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2012
Entry Details
PubMed