BDBM2321 2-(cyclopentylsulfanyl)-6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydropyrimidin-4-one::S-DABO::thio-DABO 3p

SMILES CC(c1cc(=O)[nH]c(SC2CCCC2)n1)c1c(F)cccc1F

InChI Key InChIKey=CHBMGMAGCOPBHF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2321   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2321(S-DABO | 2-(cyclopentylsulfanyl)-6-[1-(2,6-difluor...)
Affinity DataIC50: 50nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2004
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Sapienza University of Rome

LigandPNGBDBM2321(S-DABO | 2-(cyclopentylsulfanyl)-6-[1-(2,6-difluor...)
Affinity DataIC50: 30nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2004
Entry Details Article
PubMed