BDBM50203012 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea::CHEMBL239767::SB-225002

SMILES Oc1cc(ccc1NC(=O)Nc1ccccc1Br)[N+]([O-])=O

InChI Key InChIKey=MQBZVUNNWUIPMK-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50203012   

TargetC-X-C chemokine receptor type 2(Human)
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50203012(SB-225002 | 1-(2-bromophenyl)-3-(2-hydroxy-4-nitro...)
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50203012(SB-225002 | 1-(2-bromophenyl)-3-(2-hydroxy-4-nitro...)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50203012(SB-225002 | 1-(2-bromophenyl)-3-(2-hydroxy-4-nitro...)
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]IL8 from human recombinant CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50203012(SB-225002 | 1-(2-bromophenyl)-3-(2-hydroxy-4-nitro...)
Affinity DataIC50: 22nMAssay Description:Binding affinity to CXCR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50203012(SB-225002 | 1-(2-bromophenyl)-3-(2-hydroxy-4-nitro...)
Affinity DataIC50: 3.00E+3nMAssay Description:Binding affinity to CXCR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50203012(SB-225002 | 1-(2-bromophenyl)-3-(2-hydroxy-4-nitro...)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at CXCR1 assessed as inhibition of CXCL8 binding by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50203012(SB-225002 | 1-(2-bromophenyl)-3-(2-hydroxy-4-nitro...)
Affinity DataIC50: 198nMAssay Description:Antagonist activity against CXCR2 (unknown origin) by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50203012(SB-225002 | 1-(2-bromophenyl)-3-(2-hydroxy-4-nitro...)
Affinity DataIC50: 22nMAssay Description:Displacement of 125I-IL-8 from CXCR2 (unknown origin) expressed in CHO cell membrane incubated for 1 hr by liquid scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed