BDBM50370572 CHEMBL85606::SB-277011

SMILES O=C(N[C@H]1CC[C@H](CCN2CCc3cc(ccc3C2)C#N)CC1)c1ccnc2ccccc12

InChI Key InChIKey=OLWRVVHPJFLNPW-UHFFFAOYSA-N

Data  26 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50370572   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]dofetidile from human ERG by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG channel by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]Dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataIC50: 631nMAssay Description:Inhibition of human ERG tail current expressed in HEK293 cells after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataIC50: 676nMAssay Description:Inhibition of human ERG transfected in HEK293 cells assessed as reduction in tail current by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  3.98nMAssay Description:Binding affinity to human DRD3 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  3.98nMAssay Description:Antagonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  3.98nMAssay Description:Antagonist activity at human dopamine D3 receptor by cell based GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  4nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells after 90 mins by [35S]-GTPgamma S assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation counter metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  6.30nMAssay Description:Displacement of [125I]-7-OH-PIPAT from rat brain dopamine D3 receptor after 45 mins by microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]-spiperone from human dopamine D3 receptor expressed in CHO-K1 cell membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  10nMAssay Description:Binding affinity towards human Dopamine receptor D3 by displacement of [125I]iodosulpiride expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Rat)
Aptuit

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  10.7nMAssay Description:Inhibition of [125I]-iodosulpiride binding to rat Dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2020
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  11.2nMAssay Description:Inhibition of [125I]iodosulpiride binding to human Dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  398nMAssay Description:Binding affinity to human DRD2 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  398nMAssay Description:Antagonist activity at dopamine D2 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  398nMAssay Description:Antagonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  490nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes coexpressing Galpha16 after 120 mins by liquid scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2018
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor expressed in CHO-K1 cell membranes after 120 mins by liquid scintillation counter meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2017
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  501nMAssay Description:Displacement of [125I]-7-OH-PIPAT from rat brain dopamine D2 receptor after 45 mins by microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  631nMAssay Description:Antagonist activity at histamine H1 receptor by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  631nMAssay Description:Displacement of [3H]-dofetilide from human ERG potassium channel by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity towards human Dopamine receptor D2 by displacement of [125I]iodosulpiride expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2018
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [125I]iodosulpiride from human Dopamine receptor D2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  1.05E+3nMAssay Description:Inhibition of [125I]iodosulpiride binding to human Dopamine D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  2.82E+3nMAssay Description:Inhibition of [125I]iodosulpiride binding to rat Dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi:  5.16E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2020
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50370572(SB-277011 | CHEMBL85606)
Affinity DataKi: <1.00E+4nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells after 90 mins by [35S]-GTPgamma S assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2017
Entry Details Article
PubMed