BDBM50004923 (+/-)-SKF-38393::1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol::1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol (SK&F 38393)::1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol(SKF 38393)::1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrochloride(SKF 38393)::CHEMBL286080::CHEMBL505308::CHEMBL542700::RS(+/-)SKF 383931-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol::SK&F-38393::SK-38393::SKF 38393::SKF-38393::US9359372, SKF38393::cid_147514

SMILES Oc1cc2CCNCC(c3ccccc3)c2cc1O

InChI Key InChIKey=JUDKOGFHZYMDMF-UHFFFAOYSA-N

Data  22 KI  4 IC50  4 Kd  12 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 42 hits for monomerid = 50004923   

TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKd:  4.60E+4nMAssay Description:In vitro affinity at wild type Dopamine receptor D2 on C6 (glioma) cell membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Fraunhofer Institute For Translational Medicine and Pharmacology (Itmp) and Fraunhofer Cluster of Excellence For Immune Mediated Diseases (Cimd

LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataIC50: 2.63E+3nMAssay Description:Primary assay principle based on quenched FRET peptide substrate of SARS-CoV-2 3CL-Pro (lhs). Inhibiting compounds reduce fluorescence signal relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details Article

TargetD(1A) dopamine receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataEC50:  170nMAssay Description:Agonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataIC50: 3.44E+4nMAssay Description:Tested for Dopamine receptor activity by the inhibition against spiroperidol binding to rat caudate tissue.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2018
Entry Details Article
PubMed
TargetAdenylate cyclase type 1(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataEC50:  71nMAssay Description:Tested for ability to stimulate dopamine sensitive adenylate cyclase in rat caudate homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2018
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataEC50:  130nMAssay Description:Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataEC50: >1.00E+4nMAssay Description:Formation of cAMP on Dopamine receptor D2 in vitro in rat intermediate lobeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataEC50:  386nMAssay Description:Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Gedeon Richter Plc., Gy�Mroi�T 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataEC50:  1.38E+3nMAssay Description:Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2016
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataEC50:  180nMAssay Description:Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKd:  1.35E+5nMAssay Description:In vitro affinity at mutant D2 receptor (S197A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKd:  3.90E+4nMAssay Description:In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetPOsterior Segregation(Caenorhabditis elegans)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataEC50:  1.09E+5nMAssay Description:Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2011
Entry Details
PCBioAssay
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKd:  1.80E+4nMAssay Description:In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataEC50:  386nMAssay Description:Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataIC50: 190nMAssay Description:Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataIC50: 7.20E+5nMAssay Description:Displacement of [3H]YM-09151-2 (60 pm) from dopamine receptor D2 in crude membrane fraction of rat brain corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetZinc finger protein mex-5(Caenorhabditis elegans)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataEC50:  2.40E+4nMAssay Description:Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2011
Entry Details
PCBioAssay
TargetD(1A) dopamine receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataEC50:  248nMpH: 7.5Assay Description:For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetD(1A) dopamine receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataEC50:  140nMpH: 7.5Assay Description:The [35S]GTPγS binding assay was performed at 30 °C for 30 min containing 10 μgof membrane protein in a final volume of 100 μL with va...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  1.10nMAssay Description:The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  1.10nMAssay Description:The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  8.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  26.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  64nMAssay Description:Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  64nMAssay Description:Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Rat)
Purdue University

Curated by PDSP Ki Database
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Gedeon Richter Plc., Gy�Mroi�T 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2016
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of South Florida

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  124nMAssay Description:Displacement of [3H]SCH233930 from dopamine D5 receptor after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  160nMAssay Description:The compound was evaluated for the binding affinity towards Dopamine receptor D2 at high affinity stateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  190nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  248nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  393nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  520nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  6.87E+3nMAssay Description:Binding affinity was determined by measuring the ability to displace [125I]N-(p-aminophenethyl)-spiroperidol from Dopamine receptor D2 in rat caudate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  6.87E+3nMAssay Description:Binding affinity was determined by measuring the ability to displace [125I]N-(p-aminophenethyl)-spiroperidol from Dopamine receptor D2 in rat caudate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi:  8.80E+3nMAssay Description:The compound was evaluated for the binding affinity towards Dopamine receptor D2 at low affinity stateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM50004923(CHEMBL542700 | 1-Phenyl-2,3,4,5-tetrahydro-1H-benz...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed